pbk modelling software platforms  (Joint Research Center)

Journal: ALTEX

Article Title: Probabilistic Risk Assessment – The Keystone for the Future of Toxicology

doi: 10.14573/altex.2201081

Figure Lengend Snippet: Major workshops on physiology-based pharmacokinetic/toxicokinetic modeling (PBPK) for risk assessment

Article Snippet: EPAA & EURL ECVAM: Potential for further integration of toxicokinetic modelling into the prediction of in vivo dose-response curves without animal experiments, 2011, Joint Research Centre, Italy ( ) , The aim of the workshop was to critically appraise PBK modelling software platforms as well as a more detailed state-of-the-art overview of non-animal based PBK parameterization tools. Such as: 1) Identification of gaps in non-animal test methodology for the assessment of ADME. 2) Addressing user-friendly PBK software tools and free-to-use web applications. 3) Understanding the requirements for wider and increased take up and use of PBK modelling by regulators, risk assessors and toxicologists in general. 4) Tackling the aspect of obtaining in vivo human toxicokinetic reference data via micro-dosing following the increased interest by the research community, regulators, and politicians.

Techniques: In Vitro, Comparison, In Vivo, Biomarker Discovery, Software, Selection, In Silico, Construct